PUBLICATIONS

2023

Targeting SWI/SNF ATPases in H3.3K27M diffuse intrinsic pontine gliomas.

Mota M, Sweha SR, Pun M, Natarajan SK, Ding Y, Chung C, Hawes D, Yang F, Judkins AR, Samajdar S, Cao X, Xiao L, Parolia A, Chinnaiyan AM, Venneti S.

Proc Natl Acad Sci U S A. 2023 May 2;120(18):e2221175120. doi: 10.1073/pnas.2221175120. Epub 2023 Apr 24.

Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways.

Pun M, Pratt D, Nano PR, Joshi PK, Jiang L, Englinger B, Rao A, Cieslik M, Chinnaiyan AM, Aldape K, Pfister S, Filbin MG, Bhaduri A, Venneti S.

Acta Neuropathol Commun. 2023 Feb 9;11(1):25. doi: 10.1186/s40478-023-01514-z

β-catenin-driven differentiation is a tissue-specific epigenetic vulnerability in adrenal cancer.

Mohan DR, Borges KS, Finco I, LaPensee CR, Rege J, Solon AL, Little DW, Else T, Almeida MQ, Dang D, Haggerty-Skeans J, Apfelbaum AA, Vinco M, Wakamatsu A, Mariani BMP, Amorim LC, Latronico AC, Mendonca BB, Zerbini MCN, Lawlor ER, Ohi R, Auchus RJ, Rainey WE, Marie SKN, Giordano TJ, Venneti S, Fragoso MCBV, Breault DT, Lerario AM, Hammer GD.

Cancer Res. 2023 May 2:CAN-22-2712. doi: 10.1158/0008-5472.CAN-22-2712.

Metabolomic profiles of human glioma inform patient survival.

Scott AJ, Correa LO, Edwards D, Sun Y, Ravikumar V, Andren AC, Zhang L, Srinivasan S, Jairath N, Verbal K, Muraszko K, Sagher O, Carty SA, Hervey-Jumper S, Orringer D, Kim MM, Junck L, Umemura Y, Leung D, Venneti S, Camelo-Piragua S, Lawrence TS, Ippolito JE, Al-Holou WN, Chinnaiyan P, Heth J, Rao A, Lyssiotis CA, Wahl DR.

Antioxid Redox Signal. 2023 Feb 27. doi: 10.1089/ars.2022.0085.

2022

Glioblastoma stem cell HISTArionics.

Natarajan SK, Venneti S.

Cell Stem Cell. 2022 Nov 3;29(11):1509-1510. doi: 10.1016/j.stem.2022.10.004.

H3.3-G34 mutations impair DNA repair and promote cGAS/STING-mediated immune responses in pediatric high-grade glioma models.

Haase S, Banerjee K, Mujeeb AA, Hartlage CS, Núñez FM, Núñez FJ, Alghamri MS, Kadiyala P, Carney S, Barissi MN, Taher AW, Brumley EK, Thompson S, Dreyer JT, Alindogan CT, Garcia-Fabiani MB, Comba A, Venneti S, Ravikumar V, Koschmann C, Carcaboso ÁM, Vinci M, Rao A, Yu JS, Lowenstein PR, Castro MG.

J Clin Invest. 2022 Nov 15;132(22):e154229. doi: 10.1172/JCI154229.

Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma.

Messinger D, Harris MK, Cummings JR, Thomas C, Yang T, Sweha SR, Woo R, Siddaway R, Burkert M, Stallard S, Qin T, Mullan B, Siada R, Ravindran R, Niculcea M, Dowling A, Bradin J, Ginn KF, Gener MAH, Dorris K, Vitanza NA, Schmidt SV, Spitzer J, Jiang L, Filbin MG, Cao X, Castro MG, Lowenstein PR, Mody R, Chinnaiyan A, Desprez PY, McAllister S, Dun MD, Hawkins C, Waszak SM, Venneti S, Koschmann C, Yadav VN.

Neuro Oncol. 2022 May 23:noac141. doi: 10.1093/neuonc/noac141.

Serial H3K27M cell-free tumor DNA (cf-tDNA) tracking predicts ONC201 treatment response and progression in diffuse midline glioma.

Cantor E, Wierzbicki K, Tarapore RS, Ravi K, Thomas C, Cartaxo R, Yadav VN, Ravindran R, Bruzek AK, Wadden J, John V, Babila CM, Cummings JR, Kawakibi AR, Ji S, Ramos J, Paul A, Walling D, Leonard M, Robertson P, Franson A, Mody R, Garton HJL, Venneti S, Odia Y, Kline C, Vitanza NA, Khatua S, Mueller S, Allen JE, Gardner S, Koschmann C.

Neuro Oncol. 2022 Feb 6:noac030

Recurrent ACVR1 mutations in posterior fossa ependymoma.

Pratt D, Lucas CG, Selvam PP, Abdullaev Z, Ketchum C, Quezado M, Armstrong TS, Gilbert MR, Papanicolau-Sengos A, Raffeld M, Choo-Wosoba H, Chan P, Whipple N, Nasrallah M, Santi M, Ramaswamy V, Giannini C, Ritzmann TA, Grundy RG, Burford A, Jones C, Hawkins C, Venneti S, Solomon DA, Aldape K.

Acta Neuropathol. 2022 Aug;144(2):373-376.

ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization.

Qin T, Mullan B, Ravindran R, Messinger D, Siada R, Cummings JR, Harris M, Muruganand A, Pyaram K, Miklja Z, Reiber M, Garcia T, Tran D, Danussi C, Brosnan-Cashman J, Pratt D, Zhao X, Rehemtulla A, Sartor MA, Venneti S, Meeker AK, Huse JT, Morgan MA, Lowenstein PR, Castro MG, Yadav VN, Koschmann C.

Cell Rep. 2022 Jan 11;38(2):110216. doi: 10.1016/j.celrep.2021.110216.

2021

Epigenetically defined therapeutic targeting in H3.3G34R/V high-grade gliomas.

Sweha SR, Chung C, Natarajan SK, Panwalkar P, Pun M, Ghali A, Bayliss J, Pratt D, Shankar A, Ravikumar V, Rao A, Cieslik M, Wilder-Romans K, Scott AJ, Wahl DR, Jessa S, Kleinman CL, Jabado N, Mackay A, Jones C, Martinez D, Santi M, Judkins AR, Yadav VN, Qin T, Phoenix TN, Koschmann CJ, Baker SJ, Chinnaiyan AM, Venneti S.

Sci Transl Med. 2021 Oct 13;13(615):eabf7860. doi: 10.1126/scitranslmed.abf7860. Epub 2021 Oct 13.

Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas.

Panwalkar P, Tamrazi B, Dang D, Chung C, Sweha S, Natarajan SK, Pun M, Bayliss J, Ogrodzinski MP, Pratt D, Mullan B, Hawes D, Yang F, Lu C, Sabari BR, Achreja A, Heon J, Animasahun O, Cieslik M, Dunham C, Yip S, Hukin J, Phillips JJ, Bornhorst M, Griesinger AM, Donson AM, Foreman NK, Garton HJL, Heth J, Muraszko K, Nazarian J, Koschmann C, Jiang L, Filbin MG, Nagrath D, Kool M, Korshunov A, Pfister SM, Gilbertson RJ, Allis CD, Chinnaiyan AM, Lunt SY, Blüml S, Judkins AR, Venneti S.

Sci Transl Med. 2021 Oct 6;13(614):eabc0497. doi: 10.1126/scitranslmed.abc0497. Epub 2021 Oct 6. 

Comparative Molecular Analysis of Primary Central Nervous System Lymphomas and Matched Vitreoretinal Lymphomas by Vitreous Liquid Biopsy.

Balikov DA, Hu K, Liu CJ, Betz BL, Chinnaiyan AM, Devisetty LV, Venneti S, Tomlins SA, Cani AK, Rao RC.

Int J Mol Sci. 2021 Sep 16;22(18):9992. doi: 10.3390/ijms22189992.

Autopsy findings of previously described case of diffuse intrinsic pontine glioma-like tumor with EZHIP expression and molecular features of PFA ependymoma.

Alturkustani M, Cotter JA, Mahabir R, Hawes D, Koschmann C, Venneti S, Judkins AR, Szymanski LJ.

Acta Neuropathol Commun. 2021 Jun 23;9(1):113. doi: 10.1186/s40478-021-01215-5.

2020

Expression of the of the androgen receptor governs radiation resistance in a subset of glioblastomas vulnerable to anti-androgen therapy.

Werner CK, Nna UJ, Sun H, Wilder-Romans K, Dresser J, Kothari AU, Zhou W, Yao Y, Rao A, Stallard S, Koschmann C, Bor T, Debinski W, Hegedus AM, Morgan MA, Venneti S, Baskin-Bey E, Spratt DE, Colman H, Sarkaria JN, Chinnaiyan AM, Eisner JR, Speers C, Lawrence TS, Strowd RE, Wahl DR.

Mol Cancer Ther. 2020 Aug 12:molcanther.0095.2020. doi: 10.1158/1535-7163.

Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

Chung C, Sweha SR, Pratt D, Tamrazi B, Panwalkar P, Banda A, Bayliss J, Hawes D, Yang F, Lee HJ, Shan M, Cieslik M, Qin T, Werner CK, Wahl DR, Lyssiotis CA, Bian Z, Shotwell JB, Yadav VN, Koschmann C, Chinnaiyan AM, Blüml S, Judkins AR, Venneti S.

Cancer Cell 38, 1–16, September 14, 2020

Multiple system atrophy pathology is associated with primary Sjögren's syndrome.

Conway KS, Camelo-Piragua S, Fisher-Hubbard A, Perry WR, Shakkottai VG, Venneti S.

JCI Insight. 2020 Aug 6;5(15):138619. doi: 10.1172/jci.insight.138619.

Everolimus improves the efficacy of dasatinib in PDGFRα-driven glioma.

Miklja Z, Yadav VN, Cartaxo RT, Siada R, Thomas CC, Cummings JR, Mullan B, Stallard S, Paul A, Bruzek AK, Wierzbicki K, Yang T, Garcia T, Wolfe I, Leonard M, Robertson PL, Garton HJ, Wahl DR, Parmar HA, Sarkaria JN, Kline C, Mueller S, Nicolaides T, Glasser C, Leary SES, Venneti S, Kumar-Sinha C, Chinnaiyan AM, Mody R, Pai MP, Phoenix TN, Marini BL, Koschmann C.

J Clin Invest. 2020 Jun 30:133310. doi: 10.1172/JCI133310. Online ahead of print.

H3K27M-mutant diffuse midline glioma with extensive intratumoral microthrombi in a young adult with COVID-19-associated coagulopathy.

Pun M, Haggerty-Skeans J, Pratt D, Fudym Y, Al-Holou WN, Camelo-Piragua S, Venneti S.

Acta Neuropathol. 2020 Aug;140(2):227-229. doi: 10.1007/s00401-020-02184-0. Epub 2020 Jun 29.

Incidental Massive Hydrocephalus Associated With an Unruptured Choroid Plexus Arteriovenous Malformation and Complete Agenesis of the Corpus Callosum Found in an Adult at Autopsy.

Conway K, Smith Z, Nguyen T, Hlavaty L, Venneti S, Camelo-Piragua S, Webb M.

Am J Forensic Med Pathol. 2020 Jun 20. doi: 10.1097/PAF.0000000000000562.

SMARCB1 loss induces druggable cyclin D1 deficiency via upregulation of MIR17HG in atypical teratoid rhabdoid tumors.

Xue Y, Zhu X, Meehan B, Venneti S, Martinez D, Morin G, Maïga RI, Chen H, Papadakis AI, Johnson RM, O'Sullivan MJ, Erdreich-Epstein A, Gotlieb WH, Park M, Judkins AR, Pelletier J, Foulkes WD, Rak J, Huang S.J Pathol. 2020 Jun 19:e5493. doi: 10.1002/path.5493. Online ahead of print.

cIMPACT-NOW update 7: advancing the molecular classification of ependymal tumors.

Ellison DW, Aldape KD, Capper D, Fouladi M, Gilbert MR, Gilbertson RJ, Hawkins C, Merchant TE, Pajtler K, Venneti S, Louis DN.Brain Pathol. 2020 Jun 5. doi: 10.1111/bpa.12866. Online ahead of print.

Diffuse intrinsic pontine glioma-like tumor with EZHIP expression and molecular features of PFA ependymoma.

Pratt D, Quezado M, Abdullaev Z, Hawes D, Yang F, Garton HJL, Judkins AR, Mody R, Chinnaiyan A, Aldape K, Koschmann C, Venneti S.

Acta Neuropathol Commun. 2020 Mar 20;8(1):37. doi: 10.1186/s40478-020-00905-w.

SWI/SNF complex heterogeneity relates with polyphenotypic differentiation, prognosis and immune response in rhabdoid tumors.

Panwalkar P, Pratt D, Chung C, Dang D, Le P, Martinez D, Bayliss JM, Smith KS, Adam M, Potter S, Northcott P, Mascarenhas L, Shows J, Pawel B, Margol A, Huang A, Judkins AR, Venneti S.

Neuro Oncol. 2020 Jan 8. 

2019

Glutamine Metabolism in Brain Tumors.

Natarajan SK, Venneti S.

Cancers (Basel). 2019 Oct 24;11(11).

Integrating ependymoma molecular subgroups into clinical trials.

Venneti S.

Neuro Oncol. 2019 Oct 9;21(10):1219-1220

Poly Combs the Immune System: PRC2 Loss in Malignant Peripheral Nerve Sheath Tumors Can Dampen Immune Responses.

Natarajan SK, Venneti S.

Cancer Res. 2019 Jul 1;79(13):3172-3173

Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine Glioma.

Katagi H, Louis N, Unruh D, Sasaki T, He X, Zhang A, Ma Q, Piunti A, Shimazu Y, Lamano JB, Carcaboso AM, Tian X, Seluanov A, Gorbunova V, Laurie KL, Kondo A, Wadhwani NR, Lulla R, Goldman S, Venneti S, Becher OJ, Zou L, Shilatifard A, Hashizume R.

Clin Cancer Res. 2019 Sep 15;25(18):5572-5583.

PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism.

Jain SU, Do TJ, Lund PJ, Rashoff AQ, Diehl KL, Cieslik M, Bajic A, Juretic N, Deshmukh S, Venneti S, Muir TW, Garcia BA, Jabado N, Lewis PW.

Nat Commun. 2019 May 13;10(1):2146

Pediatric Atypical Teratoid/Rhabdoid Tumors of the Brain: Identification of Metabolic Subgroups Using In Vivo 1H-MR Spectroscopy.

Tamrazi B, Venneti S, Margol A, Hawes D, Cen SY, Nelson M, Judkins A, Biegel J, Blüml S.

AJNR Am J Neuroradiol. 2019 May;40(5):872-877

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response.

Núñez FJ, Mendez FM, Kadiyala P, Alghamri MS, Savelieff MG, Garcia-Fabiani MB, Haase S, Koschmann C, Calinescu AA, Kamran N, Saxena M, Patel R, Carney S, Guo MZ, Edwards M, Ljungman M, Qin T, Sartor MA, Tagett R, Venneti S, Brosnan-Cashman J, Meeker A, Gorbunova V, Zhao L, Kremer DM, Zhang L, Lyssiotis CA, Jones L, Herting CJ, Ross JL, Hambardzumyan D, Hervey-Jumper S, Figueroa ME, Lowenstein PR, Castro MG.

Sci Transl Med. 2019 Feb 13;11(479)

CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary.

Xue Y, Meehan B, Macdonald E, Venneti S, Wang XQD, Witkowski L, Jelinic P, Kong T, Martinez D, Morin G, Firlit M, Abedini A, Johnson RM, Cencic R, Patibandla J, Chen H, Papadakis AI, Auguste A, de Rink I, Kerkhoven RM, Bertos N, Gotlieb WH, Clarke BA, Leary A, Witcher M, Guiot MC, Pelletier J, Dostie J, Park M, Judkins AR, Hass R, Levine DA, Rak J, Vanderhyden B, Foulkes WD, Huang S.

Nat Commun. 2019 Feb 4;10(1):558. doi: 10.1038/s41467-018-06958-9.

SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer.

Xue Y, Meehan B, Fu Z, Wang XQD, Fiset PO, Rieker R, Levins C, Kong T, Zhu X, Morin G, Skerritt L, Herpel E, Venneti S, Martinez D, Judkins AR, Jung S, Camilleri-Broet S, Gonzalez AV, Guiot MC, Lockwood WW, Spicer JD, Agaimy A, Pastor WA, Dostie J, Rak J, Foulkes WD, Huang S.

Nat Commun. 2019 Feb 4;10(1):557. doi: 10.1038/s41467-019-08380-1.

2018

BRAF activating mutations involving the β3-αC loop in V600E-negative anaplastic pleomorphic xanthoastrocytoma.

Pratt D, Camelo-Piragua S, McFadden K, Leung D, Mody R, Chinnaiyan A, Koschmann C, Venneti S.

Acta Neuropathol Commun. 2018 Mar 15;6(1):24. doi: 10.1186/s40478-018-0525-1.

CSF H3F3A K27M circulating tumor DNA copy number quantifies tumor growth and in vitro treatment response.

Stallard S, Savelieff MG, Wierzbicki K, Mullan B, Miklja Z, Bruzek A, Garcia T, Siada R, Anderson B, Singer BH, Hashizume R, Carcaboso AM, McMurray KQ, Heth J, Muraszko K, Robertson PL, Mody R, Venneti S, Garton H, Koschmann C.

Acta Neuropathol Commun. 2018 Aug 15;6(1):80. doi: 10.1186/s40478-018-0580-7. 

Medulloblastoma therapy generates risk of a poorly-prognostic H3 wild-type subgroup of diffuse intrinsic pontine glioma: a report from the International DIPG Registry.

Gits HC, Anderson M, Stallard S, Pratt D, Zon B, Howell C, Kumar-Sinha C, Vats P, Kasaian K, Polan D, Matuszak M, Spratt DE, Leonard M, Qin T, Zhao L, Leach J, Chaney B, Escorza NY, Hendershot J, Jones B, Fuller C, Leary S, Bartels U, Bouffet E, Yock TI, Robertson P, Mody R, Venneti S, Chinnaiyan AM, Fouladi M, Gottardo NG, Koschmann C.

Acta Neuropathol Commun. 2018 Jul 26;6(1):67. doi: 10.1186/s40478-018-0570-9.

In Vivo PET Assay of Tumor Glutamine Flux and Metabolism: In-Human Trial of 18F-(2S,4R )-4-Fluoroglutamine.

Dunphy MPS, Harding JJ, Venneti S, Zhang H, Burnazi EM, Bromberg J, Omuro AM, Hsieh JJ, Mellinghoff IK, Staton K, Pressl C, Beattie BJ, Zanzonico PB, Gerecitano JF, Kelsen DP, Weber W, Lyashchenko SK, Kung HF, Lewis JS.

Radiology. 2018 Jan 31:162610. doi: 10.1148/radiol.2017162610.

Circumscribed/non-diffuse histology confers a better prognosis in H3K27M-mutant gliomas.

Pratt D, Natarajan SK, Banda A, Giannini C, Vats P, Koschmann C, Mody R, Chinnaiyan A, Venneti S.

Acta Neuropathol. 2018 Feb;135(2):299-301. doi: 10.1007/s00401-018-1805-3.

2017

Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome.

Panwalkar P, Clark J, Ramaswamy V, Hawes D, Yang F, Dunham C, Yip S, Hukin J, Sun Y, Schipper MJ, Chavez L, Margol A, Pekmezci M, Chung C, Banda A, Bayliss JM, Curry SJ, Santi M, Rodriguez FJ, Snuderl M, Karajannis MA, Saratsis AM, Horbinski CM, Carret AS, Wilson B, Johnston D, Lafay-Cousin L, Zelcer S, Eisenstat D, Silva M, Scheinemann K, Jabado N, McNeely PD, Kool M, Pfister SM, Taylor MD, Hawkins C, Korshunov A, Judkins AR, Venneti S.

Acta Neuropathol. 2017 Jul 21. doi: 10.1007/s00401-017-1752-4.

Multi-focal sequencing of a diffuse intrinsic pontine glioma establishes PTEN loss as an early event

Carl Koschmann, Zishaan Farooqui, Katayoon Kasaian, Xuhong Cao, Daniel Zamler, Stefanie Stallard, Sriram Venneti, Shawn Hervey-Jumper, Hugh Garton, Karin Muraszko, Luigi Franchi, Patricia L. Robertson, Marcia Leonard, Valerie Opipari, Maria G. Castro, Pedro R. Lowenstein, Arul Chinnaiyan & Rajen Mody

npj Precision Oncology 1, Article number: 32 (2017) doi:10.1038/s41698-017-0033-y

Rapid intraoperative histology of unprocessed surgical specimens via fibre-laser-based stimulated Raman scattering microscopy.

Orringer DA, Pandian B, Niknafs YS, Hollon TC, Boyle J, Lewis S, Garrard M, Hervey-Jumper SL, Garton HJL, Maher CO, Heth JA, Sagher O, Wilkinson DA, Snuderl M, Venneti S, Ramkissoon SH, McFadden KA, Fisher-Hubbard A, Lieberman AP, Johnson TD, Xie XS, Trautman JK, Freudiger CW, Camelo-Piragua S.

Nat Biomed Eng. 2017;1. pii: 0027. doi: 10.1038/s41551-016-0027. Epub 2017 Feb 6.

Blood-brain barrier-adapted precision medicine therapy for pediatric brain tumors.

Marini BL, Benitez LL, Zureick AH, Salloum R, Gauthier AC, Brown J, Wu YM, Robinson DR, Kumar C, Lonigro R, Vats P, Cao X, Kasaian K, Anderson B, Mullan B, Chandler B, Linzey JR, Camelo-Piragua SI, Venneti S, McKeever PE, McFadden KA, Lieberman AP, Brown N, Shao L, Leonard MAS, Junck L, McKean E, Maher CO, Garton HJL, Muraszko KM, Hervey-Jumper S, Mulcahy-Levy JM, Green A, Hoffman LM, Dorris K, Vitanza NA, Wang J, Schwartz J, Lulla R, Smiley NP, Bornhorst M, Haas-Kogan DA, Robertson PL, Chinnaiyan AM, Mody R, Koschmann C.

Transl Res. 2017 Oct;188:27.e1-27.e14. doi: 10.1016/j.trsl.2017.08.001. Epub 2017 Aug 10.

Glutaminolysis: A Hallmark of Cancer Metabolism.

Yang L, Venneti S, Nagrath D.

Annu Rev Biomed Eng. 2017 Jun 21;19:163-194.

Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis.

Xu T, Zhang H, Park SS, Venneti S, Kuick R, Ha K, Michael LE, Santi M, Uchida C, Uchida T, Srinivasan A, Olson JM, Dlugosz AA, Camelo-Piragua S, Rual JF.

Neoplasia. 2017 Mar;19(3):216-225.

Metabolic Reprogramming in Brain Tumors.

Venneti S, Thompson CB.

Annu Rev Pathol. 2017 Jan 24;12:515-545.

2016

Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas.

Bayliss J, Mukherjee P, Lu C, Jain SU, Chung C, Martinez D, Sabari B, Margol AS, Panwalkar P, Parolia A, Pekmezci M, McEachin RC, Cieslik M, Tamrazi B, Garcia BA, La Rocca G, Santi M, Lewis PW, Melnik A, Allis DC, Thompson CB, Chinnaiyan AM, Judkins AR, Venneti S.

Science Translational Medicine. 23 Nov 2016: Vol. 8, Issue 366, pp. 366ra161
 

Brainstem Low-Grade Gliomas in Children-Excellent Outcomes With Multimodality Therapy.

Upadhyaya SA, Koschmann C, Muraszko K, Venneti S, Garton HJ, Hamstra DA, Maher CO, Betz BL, Brown NA, Wahl D, Weigelin HC, DuRoss KE, Leonard AS, Robertson PL.

J Child Neurol. 2016 Nov 3. pii: 0883073816675547.

Rescue of Metabolic Alterations in AR113Q Skeletal Muscle by Peripheral Androgen Receptor Gene Silencing.

Giorgetti E, Yu Z, Chua JP, Shimamura R, Zhao L, Zhu F, Venneti S, Pennuto M, Guan Y, Hung G, Lieberman AP.

Cell Rep. 2016 Sep 27;17(1):125-36. doi: 10.1016/j.celrep.2016.08.084.

Non-invasive metabolic imaging of brain tumors in the era of precision medicine

Kim M, Parolia A, Dunphy MP,  Venneti S

Nature Reviews Clinical Oncology. 2016 Jul 19. doi: 10.1038/nrclinonc.2016.108.

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape.

Lu C, Jain SU, Hoelper D, Bechet D, Molden RC, Ran L, Murphy D, Venneti S, Hameed M, Pawel BR, Wunder JS, Dickson BC, Andrulis IL, Sawyer SL, Grynspan D, Nadaf J, Fahiminiyah S, Majewski J, Thompson CB, Chi P, Garcia BA, Allis CD, Jabado N, Lewis P.  

Science. 13 MAY 2016 • VOL 352 ISSUE 6287 pp. 844-849

2015

2-Hydoxyglutarate: D/Riving Pathology in gLiomaS.

Wahl DR and Venneti S

 Brain Pathol. 2015 Nov;25(6):760-8

Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy.

Ji M, Lewis S, Camelo-Piragua S, Ramkissoon SH, Snuderl M, Venneti S, Fisher-Hubbard A, Garrard M, Fu D, Wang AC, Heth JA, Maher CO, Sanai N, Johnson TD, Freudiger CW, Sagher O, Xie XS, Orringer DA.

Sci Transl Med. 2015 Oct 14;7(309):309ra163

Hypoxia Induces Production of L-2-Hydroxyglutarate.

Intlekofer AM, Dematteo RG, Venneti S, Finley LW, Lu C, Judkins AR, Rustenburg AS, Grinaway PB, Chodera JD, Cross JR, Thompson CB.

Cell Metab. 2015 Aug 4;22(2):304-11.

Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo.

Venneti S, Dunphy MP, Zhang H, Pitter KL, Zanzonico P, Campos C, Carlin SD, La Rocca G, Lyashchenko S, Ploessl K, Rohle D, Omuro AM, Cross JR, Brennan CW, Weber WA, Holland EC, Mellinghoff IK, Kung HF, Lewis JS, Thompson CB.

Sci Transl Med. 2015 Feb 11;7(274):274ra17. doi: 10.1126/scitranslmed.aaa1009

The evolving molecular genetics of low-grade glioma.

Venneti S, Huse JT.

Adv Anat Pathol. 2015 Mar;22(2):94-101. doi: 10.1097/PAP.0000000000000049. Erratum in: Adv Anat Pathol. 2015 May;22(3):226.

Feedback circuitry between miR-218 repression and RTK activation in glioblastoma.

Mathew LK, Huangyang P, Mucaj V, Lee SS, Skuli N, Eisinger-Mathason TS, Biju K, Li B, Venneti S, Lal P, Lathia JD, Rich JN, Keith B, Simon MC.

Sci Signal. 2015 May 5;8(375):ra42. doi: 10.1126/scisignal.2005978.

MicroRNA-124 expression counteracts pro-survival stress responses in glioblastoma.

Mucaj V, Lee SS, Skuli N, Giannoukos DN, Qiu B, Eisinger-Mathason TS, Nakazawa MS, Shay JE, Gopal PP, Venneti S, Lal P, Minn AJ, Simon MC, Mathew LK.

Oncogene. 2015 Apr 23;34(17):2204-14. doi: 10.1038/onc.2014.168. Epub 2014 Jun 23.

2014

Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.

Zhang J, Fan J, Venneti S, Cross JR, Takagi T, Bhinder B, Djaballah H, Kanai M, Cheng EH, Judkins AR, Pawel B, Baggs J, Cherry S, Rabinowitz JD, Thompson CB.

Mol Cell. 2014 Oct 23;56(2):205-18. doi: 10.1016/j.molcel.2014.08.018. Epub 2014 Sep 18.

A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas.

Venneti S, Santi M, Felicella MM, Yarilin D, Phillips JJ, Sullivan LM, Martinez D, Perry A, Lewis PW, Thompson CB, Judkins AR.

Acta Neuropathol. 2014 Nov;128(5):743-53. doi: 10.1007/s00401-014-1338-3. Epub 2014 Sep 9.

Serine catabolism regulates mitochondrial redox control during hypoxia.

Ye J, Fan J, Venneti S, Wan YW, Pawel BR, Zhang J, Finley LW, Lu C, Lindsten T, Cross JR, Qing G, Liu Z, Simon MC, Rabinowitz JD, Thompson CB.

Cancer Discov. 2014 Dec;4(12):1406-17. doi: 10.1158/2159-8290.CD-14-0250. Epub 2014 Sep 3.

Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation.

Lee JV, Carrer A, Shah S, Snyder NW, Wei S, Venneti S, Worth AJ, Yuan ZF, Lim HW, Liu S, Jackson E, Aiello NM, Haas NB, Rebbeck TR, Judkins A, Won KJ, Chodosh LA, Garcia BA, Stanger BZ, Feldman MD, Blair IA, Wellen KE.

Cell Metab. 2014 Aug 5;20(2):306-19. doi: 10.1016/j.cmet.2014.06.004. Epub 2014 Jul 3.

miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma.

Mathew LK, Skuli N, Mucaj V, Lee SS, Zinn PO, Sathyan P, Imtiyaz HZ, Zhang Z, Davuluri RV, Rao S, Venneti S, Lal P, Lathia JD, Rich JN, Keith B, Minn AJ, Simon MC.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):291-6. doi: 10.1073/pnas.1314341111. Epub 2013 Dec 24.

2013

Induction of sarcomas by mutant IDH2.

Lu C, Venneti S, Akalin A, Fang F, Ward PS, Dematteo RG, Intlekofer AM, Chen C, Ye J, Hameed M, Nafa K, Agaram NP, Cross JR, Khanin R, Mason CE, Healey JH, Lowe SW, Schwartz GK, Melnick A, Thompson CB.

Genes Dev. 2013 Sep 15;27(18):1986-98. doi: 10.1101/gad.226753.113.

Histone 3 lysine 9 trimethylation is differentially associated with isocitrate dehydrogenase mutations in oligodendrogliomas and high-grade astrocytomas.

Venneti S, Felicella MM, Coyne T, Phillips JJ, Gorovets D, Huse JT, Kofler J, Lu C, Tihan T, Sullivan LM, Santi M, Judkins AR, Perry A, Thompson CB.

J Neuropathol Exp Neurol. 2013 Apr;72(4):298-306. doi: 10.1097/NEN.0b013e3182898113.

Metabolic modulation of epigenetics in gliomas.

Venneti S, Thompson CB.

Brain Pathol. 2013 Mar;23(2):217-21. doi: 10.1111/bpa.12022. Review.

Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas.

Venneti S, Garimella MT, Sullivan LM, Martinez D, Huse JT, Heguy A, Santi M, Thompson CB, Judkins AR.

Brain Pathol. 2013 Sep;23(5):558-64. doi: 10.1111/bpa.12042. Epub 2013 Mar 6.

Immunohistochemical expression of glypican-3 in pediatric tumors: an analysis of 414 cases.

Chan ES, Pawel BR, Corao DA, Venneti S, Russo P, Santi M, Sullivan LM.

Pediatr Dev Pathol. 2013 Jul-Aug;16(4):272-7. doi: 10.2350/12-06-1216-OA.1. Epub 2013 Mar 26.

PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma.

Phillips JJ, Aranda D, Ellison DW, Judkins AR, Croul SE, Brat DJ, Ligon KL, Horbinski C, Venneti S, Zadeh G, Santi M, Zhou S, Appin CL, Sioletic S, Sullivan LM, Martinez-Lage M, Robinson AE, Yong WH, Cloughesy T, Lai A, Phillips HS, Marshall R, Mueller S, Haas-Kogan DA, Molinaro AM, Perry A.

Brain Pathol. 2013 Sep;23(5):565-73. doi: 10.1111/bpa.12043. Epub 2013 Mar 18.

Endoscopic endonasal resection of anterior skull base meningiomas and mucosa: implications for resection, reconstruction, and recurrence.

Lee JY, Barroeta JE, Newman JG, Chiu AG, Venneti S, Grady MS.

J Neurol Surg A Cent Eur Neurosurg. 2013 Jan;74(1):12-7. doi: 10.1055/s-0032-1322594. Epub 2012 Oct 26.

2012

Optic nerve biopsy in the management of progressive optic neuropathy.

Levin MH, Ney JJ, Venneti S, Moster ML, Balcer LJ, Volpe NJ, Gausas RE, Liu GT, Vagefi MR, Galetta SL.

J Neuroophthalmol. 2012 Dec;32(4):313-20. doi: 10.1097/WNO.0b013e31825be81e.

Molecular imaging of microglia/macrophages in the brain.

Venneti S, Lopresti BJ, Wiley CA.

Glia. 2013 Jan;61(1):10-23. doi: 10.1002/glia.22357. Epub 2012 May 21. Review.

MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS.

Venneti S, Boateng LA, Friedman JR, Baldwin DA, Tobias JW, Judkins AR, Mourelatos Z, Lal P.

Brain Pathol. 2012 Jul;22(4):522-9. doi: 10.1111/j.1750-3639.2011.00551.x. Epub 2011 Dec 9.

2011

Simulated brain biopsy for diagnosing neurodegeneration using autopsy-confirmed cases.

Venneti S, Robinson JL, Roy S, White MT, Baccon J, Xie SX, Trojanowski JQ.

Acta Neuropathol. 2011 Dec;122(6):737-45. doi: 10.1007/s00401-011-0880-5. Epub 2011 Sep 30.

Malignant rhabdoid tumors express stem cell factors, which relate to the expression of EZH2 and Id proteins.

Venneti S, Le P, Martinez D, Xie SX, Sullivan LM, Rorke-Adams LB, Pawel B, Judkins AR.

Am J Surg Pathol. 2011 Oct;35(10):1463-72. doi: 10.1097/PAS.0b013e318224d2cd.

Ganglioglioma arising from dysplastic cortex.

Ortiz-González XR, Venneti S, Biegel JA, Rorke-Adams LB, Porter BE.

Epilepsia. 2011 Sep;52(9):e106-8. doi: 10.1111/j.1528-1167.2011.03124.x. Epub 2011 Jun 10.

p16INK4A and p14ARF tumor suppressor pathways are deregulated in malignant rhabdoid tumors.

Venneti S, Le P, Martinez D, Eaton KW, Shyam N, Jordan-Sciutto KL, Pawel B, Biegel JA, Judkins AR.

J Neuropathol Exp Neurol. 2011 Jul;70(7):596-609. doi: 10.1097/NEN.0b013e31822146ca.

Isocitrate dehydrogenase 1 analysis differentiates gangliogliomas from infiltrative gliomas.

Horbinski C, Kofler J, Yeaney G, Camelo-Piragua S, Venneti S, Louis DN, Perry A, Murdoch G, Nikiforova M.

Brain Pathol. 2011 Sep;21(5):564-74. doi: 10.1111/j.1750-3639.2011.00480.x. Epub 2011 Mar 14.

2010

Asymmetric bilateral demyelinating optic neuropathy from tacrolimus toxicity.

Venneti S, Moss HE, Levin MH, Vagefi MR, Brozena SC, Pruitt AA, Mourelatos Z, Trojanowski JQ, Galetta SL, Balcer LJ.

J Neurol Sci. 2011 Feb 15;301(1-2):112-5. doi: 10.1016/j.jns.2010.10.014. Epub 2010 Nov 26.

Prion diseases.

Venneti S.

Clin Lab Med. 2010 Mar;30(1):293-309. doi: 10.1016/j.cll.2009.11.002.

2009

Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease.

Wiley CA, Lopresti BJ, Venneti S, Price J, Klunk WE, DeKosky ST, Mathis CA.

Arch Neurol. 2009 Jan;66(1):60-7. doi: 10.1001/archneurol.2008.511.

Imaging microglial activation during neuroinflammation and Alzheimer's disease.

Venneti S, Wiley CA, Kofler J.

J Neuroimmune Pharmacol. 2009 Jun;4(2):227-43. doi: 10.1007/s11481-008-9142-2.

PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET.

Venneti S, Lopresti BJ, Wang G, Hamilton RL, Mathis CA, Klunk WE, Apte UM, Wiley CA.

Neurobiol Aging. 2009 Aug;30(8):1217-26. doi: 10.1016/j.neurobiolaging.2007.11.005. Epub 2008 Feb 21.

2008

The positron emission tomography ligand DAA1106 binds with high affinity to activated microglia in human neurological disorders.

Venneti S, Wang G, Nguyen J, Wiley CA.

J Neuropathol Exp Neurol. 2008 Oct;67(10):1001-10. doi: 10.1097/NEN.0b013e318188b204.

Longitudinal in vivo positron emission tomography imaging of infected and activated brain macrophages in a macaque model of human immunodeficiency virus encephalitis correlates with central and peripheral markers of encephalitis and areas of synaptic degeneration.

Venneti S, Bonneh-Barkay D, Lopresti BJ, Bissel SJ, Wang G, Mathis CA, Piatak M Jr, Lifson JD, Nyaundi JO, Murphey-Corb M, Wiley CA.

Am J Pathol. 2008 Jun;172(6):1603-16. doi: 10.2353/ajpath.2008.070967. Epub 2008 May 8.

The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds to activated and infected brain macrophages in areas of synaptic degeneration: implications for PET imaging of neuroinflammation in lentiviral encephalitis.

Venneti S, Wang G, Wiley CA.

Neurobiol Dis. 2008 Feb;29(2):232-41. Epub 2007 Sep 7.

2007

Activated macrophages in HIV encephalitis and a macaque model show increased [3H](R)-PK11195 binding in a PI3-kinase-dependent manner.

Venneti S, Wang G, Wiley CA.

Neurosci Lett. 2007 Oct 16;426(2):117-22. Epub 2007 Aug 31.

The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging.

Venneti S, Wagner AK, Wang G, Slagel SL, Chen X, Lopresti BJ, Mathis CA, Wiley CA.

Exp Neurol. 2007 Sep;207(1):118-27. Epub 2007 Jun 19.

A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation.

Venneti S, Lopresti BJ, Wang G, Slagel SL, Mason NS, Mathis CA, Fischer ML, Larsen NJ, Mortimer AD, Hastings TG, Smith AD, Zigmond MJ, Suhara T, Higuchi M, Wiley CA.

J Neurochem. 2007 Sep;102(6):2118-31. Epub 2007 Jun 7.

2000 - 2006

The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging.

Venneti S, Lopresti BJ, Wiley CA.

Prog Neurobiol. 2006 Dec;80(6):308-22. Epub 2006 Dec 6. Review.

PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS.

Venneti S, Lopresti BJ, Wang G, Bissel SJ, Mathis CA, Meltzer CC, Boada F, Capuano S 3rd, Kress GJ, Davis DK, Ruszkiewicz J, Reynolds IJ, Murphey-Corb M, Trichel AM, Wisniewski SR, Wiley CA.

J Clin Invest. 2004 Apr;113(7):981-9.

NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro.

Sinor JD, Du S, Venneti S, Blitzblau RC, Leszkiewicz DN, Rosenberg PA, Aizenman E.

J Neurosci. 2000 Dec 1;20(23):8831-7.