Sriram Venneti, MD, PhD
Principal Investigator
Al and Robert Glick Family Research Professor of Pediatrics
Scientific Research Director, Chad Carr Pediatric Brain Tumor Center
Julie Taubman Reys Scholar in Cancer
Associate Professor of Pathology
Associate Professor of Pediatrics
svenneti@med.umich.edu
(734) 763-0674
Dr. Venneti is a physician-scientist (Clinical profile) and practicing neuropathologist.
Jill Bayliss, MS (University of Iowa, Biological Sciences)
Lab Manager (Research Laboratory Specialist Intermediate)
jbayliss@med.umich.edu
(734) 615-4636
Bayliss J, et al. Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas. Sci Transl Med. 2016 Nov 23;8(366):366ra161. doi: 10.1126/scitranslmed.aah6904.
Mateus Mota, Ph.D. (University of Alabama Birmingham)
Chadtough Defeat DIPG Postdoctoral research fellow
mmota@med.umich.edu
Siva Kumar Natarajan, (Undergraduate training SASTRA University)
Graduate Student, Molecular & Cellular Pathology
Mistletoe Research Fellow from the Momental Foundation
sivakn@umich.edu
Natarajan SK, Venneti S. Poly Combs the Immune System: PRC2 Loss in Malignant Peripheral Nerve Sheath Tumors Can Dampen Immune Responses. Cancer Res. 2019 Jul 1;79(13):3172-3173. doi: 10.1158/0008-5472.CAN-19-1186.
Natarajan SK, Venneti S.Glutamine Metabolism in Brain Tumors. Cancers (Basel). 2019 Oct 24;11(11):1628. doi: 10.3390/cancers11111628.
Sweha SR, Chung C, Natarajan SK, et al. Epigenetically defined therapeutic targeting in H3.3G34R/V high-grade gliomas. Sci Transl Med. 2021 Oct 13;13(615):eabf7860. doi
Panwalkar P#, Tamrazi B#, Dang D#, Chung C#, Sweha SR#, Natarajan SK# et al. Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas. .Sci Transl Med. 2021 Oct 6;13(614):eabc0497 (# equal contribution)
Derek Dang (Undergraduate training, University of Washington), Graduate Student, Molecular & Cellular Pathology
Ruth L. Kirschstein National Research Service Predoctoral Fellow (F31)
dangder@umich.edu
Panwalkar P#, Tamrazi B#, Dang D#, Chung C#, Sweha SR#, Natarajan SK.# et al. Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas. .Sci Transl Med. 2021 Oct 6;13(614):eabc0497 (# equal contribution)
James Haggerty-Skeans, (Undergraduate training University of California Los Angeles), Graduate Student, Cellular and Molecular Biology, Combined MD PhD program
Pediatric Oncology Student Training (POST) Program Fellow
Alex Lemonade Stand Foundation
jarha@med.umich.edu
Pun M#, Haggerty-Skeans J# et al. H3K27M-mutant diffuse midline glioma with extensive intratumoral microthrombi in a young adult with COVID-19-associated coagulopathy. Acta Neuropathol. 2020 Aug;140(2):227-229. doi: 10.1007/s00401-020-02184-0. Epub 2020 Jun 29. (# equal contribution).
Joanna Lum, (Undergraduate training University of Maryland), Graduate Student, Molecular & Cellular Pathology
NIH-NIGMS TPTR T32 predoctoral fellow
jolum@umich.edu
Akash Deogharkar Ph. D. (ACTREC, India)
Chadtough Defeat DIPG Postdoctoral research fellow
akdeogha@umich.edu
John McKolay, (Undergraduate training University of Michigan), Research Technician
jmckolay@umich.edu
Pranav Narayanan, Undergraduate student, University of Michigan
pranavn@umich.edu
Andreanna Fekaris, Undergraduate student, University of Michigan
afekaris@umich.edu
Matthew Pun, Ph. D. , Graduate Student in Cellular and Molecular Biology/Combined MD PhD program, Ph.D.- 2023. Current position,, Medical Student, University of Michigan
Ruth L. Kirschstein National Research Service Predoctoral Fellow (F31)
punm@umich.edu
Pun M#, Haggerty-Skeans J# et al. H3K27M-mutant diffuse midline glioma with extensive intratumoral microthrombi in a young adult with COVID-19-associated coagulopathy. Acta Neuropathol. 2020 Aug;140(2):227-229. doi: 10.1007/s00401-020-02184-0. Epub 2020 Jun 29. (# equal contribution).
Mota M, Sweha SR, Pun M, et al.. Targeting SWI/SNF ATPases in H3.3K27M diffuse intrinsic pontine gliomas. Proc Natl Acad Sci U S A. 2023 May 2;120(18)
Pun M,wt al. Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways. Acta Neuropathol Commun. 2023 Feb 9;11(1):25.
Sweha SR, Chung C, Natarajan SK, Panwalkar P, Pun M, et al. .Epigenetically defined therapeutic targeting in H3.3G34R/V high-grade gliomas. Sci Transl Med. 2021 Oct 13;13(615):eabf7860
Panwalkar P, Tamrazi B, Dang D, Chung C, Sweha S, Natarajan SK, Pun M, et al. Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas. Sci Transl Med. 2021 Oct 6;13(614):eabc0497.
Stefan Sweha, Ph.D. Graduate student in Neurosicence, Ph.D.- 2021. Current position, Postdoctoral Fellow, Luis Parada Lab, Memorial Sloan Kettering
Mota M, Sweha SR, Pun M, Natarajan SK, Ding Y, Chung C, Hawes D, Yang F, Judkins AR, Samajdar S, Cao X, Xiao L, Parolia A, Chinnaiyan AM, Venneti S. Targeting SWI/SNF ATPases in H3.3K27M diffuse intrinsic pontine gliomas. Proc Natl Acad Sci U S A. 2023 May 2;120(18):e2221175120. doi:
Sweha SR, et al. Epigenetically defined therapeutic targeting in H3.3G34R/V high-grade gliomas. Sci Transl Med. 2021 Oct 13;13(615):eabf7860. doi
Chung C, Sweha SR. et al. Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas. Cancer Cell. 2020 Sep 14;38(3):334-349.e9.
Panwalkar P#, Tamrazi B#, Dang D#, Chung C#, Sweha SR#, Natarajan SK.# et al. Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas. .Sci Transl Med. 2021 Oct 6;13(614):eabc0497 (# equal contribution)
Drew Pratt, M. D., Postdoctoral fellow.
Current position Assistant Professor, Dept of Pathology, National Cancer Institute.
Pratt D et al. BRAF activating mutations involving the β3-αC loop in V600E-negative anaplastic pleomorphic xanthoastrocytoma. Acta Neuropathol Commun. 2018 Mar 15;6(1):24. doi: 10.1186/s40478-018-0525-1.
Panwalkar P#, Pratt D#, Chung C# et al. SWI/SNF complex heterogeneity is related to polyphenotypic differentiation, prognosis, and immune response in rhabdoid tumors. Neuro Oncol. 2020 Jun 9;22(6):785-796. doi: 10.1093/neuonc/noaa004. (# equal contribution)
Pratt D et al. Diffuse intrinsic pontine glioma-like tumor with EZHIP expression and molecular features of PFA ependymoma. Acta Neuropathol Commun. 2020 Mar 20;8(1):37. doi: 10.1186/s40478-020-00905-w.
Chan Chung, Ph. D (Univ of Michigan). Postdoctoral fellow
Current position Assistant Professor, Dept of New Biology, DGIST, South Korea. Chan’s lab web site
Chung C, et al. Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas. Cancer Cell. 2020 Sep 14;38(3):334-349.e9.
Panwalkar P#, Tamrazi B#, Dang D#, Chung C#, Sweha SR#, Natarajan SK.# et al. Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas. .Sci Transl Med. 2021 Oct 6;13(614):eabc0497 (# equal contribution)
Panwalkar P#, Pratt D#, Chung C# et al. SWI/SNF complex heterogeneity is related to polyphenotypic differentiation, prognosis, and immune response in rhabdoid tumors. Neuro Oncol. 2020 Jun 9;22(6):785-796. doi: 10.1093/neuonc/noaa004. (# equal contribution)
Sweha SR, Chung C, et al. Epigenetically defined therapeutic targeting in H3.3G34R/V high-grade gliomas. Sci Transl Med. 2021 Oct 13;13(615):eabf7860. doi
Pooja Panwalkar, Ph.D. (ACTREC, India). Postdoctoral fellow
Current position Scientist at Fork & Goode Inc. (New York City)
Panwalkar P#, Tamrazi B#, Dang D#, Chung C#, Sweha SR#, Natarajan SK.# et al. Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas. .Sci Transl Med. 2021 Oct 6;13(614):eabc0497 (# equal contribution)
Panwalkar P#, Pratt D#, Chung C# et al. SWI/SNF complex heterogeneity is related to polyphenotypic differentiation, prognosis, and immune response in rhabdoid tumors. Neuro Oncol. 2020 Jun 9;22(6):785-796. doi: 10.1093/neuonc/noaa004. (# equal contribution)
Panwalkar P et al. Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome. Acta Neuropathol. 2017 Nov;134(5):705-714.